Latent autoimmune diabetes in adults LADA is a form of diabetes mellitus type 1 that occurs in adulthood, often with a slower course of onset than type 1 diabetes diagnosed in juveniles. The diagnosis is typically based on the finding of hyperglycemia together with the clinical impression that islet failure rather than insulin resistance is the main cause; detection of a low C-peptide and raised antibodies against the islets of Langerhans support the diagnosis. It can only be treated with the usual oral treatments for type 2 diabetes for a certain period of time,   after which insulin treatment is usually necessary, as well as long-term monitoring for complications. The concept of LADA was first introduced in ,  though The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus does not recognize the term, instead including it under the standard definition of diabetes mellitus type 1. The symptoms of latent autoimmune diabetes in adults are similar to those of other forms of diabetes: polydipsia excessive thirst and drinking , polyuria excessive urination , and often blurred vision. Glutamic acid decarboxylase autoantibody GADA , islet cell autoantibody ICA , insulinoma-associated IA-2 autoantibody, and zinc transporter autoantibody ZnT8 testing should be performed on all adults who are not obese who are diagnosed with diabetes.
Latent Autoimmune Diabetes in Adults
Latent autoimmune diabetes in adults - Wikipedia
LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid atherosclerotic plaques in patients with LADA as compared with patients with classic type 1 diabetes and type 2 diabetes. Patients with LADA were matched for age and gender in different proportions to patients with type 2 diabetes, and classic type 1 diabetes. None of the patients had clinical cardiovascular disease. All subjects underwent B-mode carotid ultrasound to detect atheroma plaques.
Latent autoimmune diabetes in adults
Diagnosing LADA has treatment implications because of high risk of progression to insulin dependency. But often there is delay in insulin therapy, as there are no recommendations for islet antibody testing in adult-onset diabetes currently. LADA clinical risk score can identify adults at high risk who may benefit from antibody testing. The optimal treatment of LADA is not established. Early insulin therapy helps to achieve good metabolic control and better long-term outcomes by preserving b-cells and endogenous C-peptide secretion.
Please take this quick survey to tell us about what happens after you publish a paper. Latent autoimmune diabetes in adults LADA prevails as a name in diabetes research although it was ranked as the second silliest name some years ago [ 1 ]. LADA describes a subgroup of patients who develop phenotypic type 2 diabetes but with markers of autoimmunity [ 2 , 3 ]. Both the age and the insulin criteria were soon questioned [ 1 , 5 ], but they also gained some support [ 6 ]. The question of how to define LADA has resulted in numerous articles and debates discussing whether LADA is a disease on its own or just a variant of type 1 diabetes [ 7 , 8 , 9 ].